CBG Is ‘the Mother of All Cannabinoids’


Even though it appears like only yesterday that CBD became a household name, people today are currently browsing for the “next major thing” in cannabis. Some have recommended that skin-friendly terpenes may well match the bill, although other folks consider that flavonoids like cannaflavins A + B (which could be a superior option to aspirin) are a dark horse contender. Nevertheless, it is one more cannabinoid — CBG — that could have the clearest path to prominence.

CBG, or cannabigerol, is a non-psychoactive compound often identified as “the mother of all cannabinoids,” a class of more than 110 organic chemical compounds discovered in the cannabis plant. It gets this name simply because its precursor, cannabigerolic acid or CBGA, is the “stem cell” from which other cannabinoids like THC and CBD are formed. Nevertheless, CBG itself is only present in trace amounts in most contemporary cannabis strains — it ordinarily comprises about 1-two % of a strain’s total cannabinoid content material. 

This tends to make extracting it and manufacturing CBG-wealthy items an costly proposition — a gram of CBG isolate tends to expense at least $45 — but it hasn’t stopped CBG oils, toothpastes, face creams, and other things from hitting the industry, and so far they’ve proved to be a hit with shoppers. As the CEO of Steve’s Goods, a Colorado-primarily based CBD firm that was amongst the initially to launch a line of CBG-precise items, told Forbes, “[CBG is] undoubtedly gaining momentum. We have personally administered CBG to thousands of people today at more than 50 events. It is the most requested item on our web-site and we supply education to thousands of receptive people today each in particular person and on line each and every month.” 

It all sounds extremely fascinating … but what precisely is CBG supposed to do, and why are people today so excited about it? 

What Are the Health-related Applications of CBG?

CBG has been studied for a wide variety of prospective purposes, from relieving glaucoma symptoms to easing the discomfort of people today with irritable bowel syndrome. Right here are some of the most promising findings:

CBG could slow the development of cancerous tumors.
A quantity of research have recommended CBG could be a helpful therapy for a number of sorts of cancer. A 2009 study in the journal Trends in Pharmacological Sciences discovered that CBG was 1 of a number of cannabinoids “shown to exert anti-proliferative/pro-apoptotic effects … in a panel of tumor cell lines,” that integrated human breast, prostate, and colorectal cancers. Along with CBD, it was the only cannabinoid to inhibit the development of prostate cancer cells. 

A lot more lately, a 2014 study in the journal Carcinogenesis bolstered the thought that CBG could be productive at treating colorectal cancer (CRC). Even though it was performed on mice rather than human subjects, the researchers discovered the outcomes encouraging sufficient to state, “CBG hampers colon cancer progression in vivo and selectively inhibits the development of CRC cells … [it] need to be regarded translationally in CRC prevention and remedy.”

CBG may well aid you unwind and really feel far better.
A 2006 study with the delightful title of “A cannabigerol extract alters behavioral despair in an animal model of depression” discovered that, at least for rats, CBG could be a helpful tool for alleviating depression. No related trials have been performed on humans, but a 2010 paper in the British Journal of Pharmacology discovered that CBG has the prospective to inhibit five-HT(1A) receptors, typically identified as serotonin receptors, which are typically a target for antidepressant drugs. 

Interestingly, a 1975 study on cannabinoids’ potential to block the brain’s uptake of GABA (a chemical connected with anxiousness and tension) is typically cited as proof of CBG’s anti-anxiousness prospective — but the study really discovered that cannabinoids like THC and CBD had been a great deal a lot more productive. 

CBG could guard your brain.
In 2015, researchers writing in the journal Neurotherapeutics investigated how CBG could have an effect on the brains of mice with Huntington’s illness, a fatal and incurable neurodegenerative illness that entails the breakdown of brain cells, major to symptoms related to Alzheimer’s. 

They discovered that CBG was “extremely active as neuroprotectant … enhancing motor deficits and preserving striatal neurons against [toxicity].” CBG also seemed to aid repair cells that had currently been broken. This gave the researchers a optimistic impression of the prospective “for the use of CBG, alone or in mixture with other phytocannabinoids or therapies, for the therapy of neurodegenerative illnesses such as [Huntington’s disease].”

CBG may well be productive at treating drug-resistant bacteria.
Like its fellow cannabinoid CBC, CBG is a helpful antifungal agent, but it definitely shines in an antimicrobial part. A 2008 paper from Italian researchers revealed that CBG “showed potent activity against a wide variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of present clinical relevance.” 

In plain English, that suggests CBG could offer you protection against staph infections that can not be treated with ordinary antibiotics.


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