From MedTech to Cannabis: A Q&A with Jennifer Raeder-Devens

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Project Yosemite, a cannabis item innovation and brand improvement organization, announced earlier this month the appointment of Jennifer Raeder-Devens as their new Chief Scientific Officer. Raeder-Devens is a veteran of the MedTech market, operating for corporations like Becton Dickinson, Cardinal Well being, Medtronic and 3M.

Prior to joining Yosemite, she was the Vice President of Investigation &amp Improvement at Becton, Dickinson, exactly where she oversaw item improvement and technologies approaches to launch infection prevention goods which includes the ChloraPrep initially-in-the-US sterile answer patient preoperative topical antiseptic. She was previously the Vice President of R&ampD, Method and Innovation at Cardinal Well being. She’s also held roles at Medtronic, 3M Drug Delivery Systems and 3M Skin Well being Division and she has a quantity of patents in drug delivery and healthcare devices.

Jennifer Raeder-Devens, Chief Scientific Officer at Project Yosemite

In November of 2018, Project Yosemite launched their initially item, OLO, which is an infused, controlled-release sublingual strip. Aspect of Raeder-Devens’ new function at the organization is the continued improvement and expansion of the OLO sublingual strip technologies platform. Andrew Mack, CEO and founder of Project Yosemite, says he’s thrilled to have Raeder-Devens on the group. “Jennifer is an really achieved scientist and engineer with comprehensive knowledge driving innovation and R&ampD in the pharmaceutical and healthcare device industries,” says Mack.

We caught up with Jennifer more than the telephone to speak about her background in the MedTech space, why she decided to jump ship to join the cannabis market and what she’s excited to operate on now.

Cannabis Sector Journal: Can you inform us about your background, which includes your operate with 3M and Medtronic? 

Jennifer Raeder-Devens: I’m coming straight from Becton Dickinson, a international med tech organization, exactly where I supervised the improvement of drug-device mixture goods for topical antiseptics. I spent about 10 years there, largely in topical drug and mixture item improvement. Prior to that, I was at 3M and Medtronic operating in drug-device mixture goods. At 3M, I was supervising a group of technologies developers for the 3M Drug Delivery Systems company. I had knowledge operating with designing and manufacturing transdermal, nasal, buccal and inhalation drug delivery mechanisms for pharmaceutical partners.

I worked on implantable drug delivery systems at Medtronic, which incorporated operating on the biocompatibility of issues like pacemakers and drug infusion pumps and optimizing them to lower infection and improve healing immediately after the implantation process.

CIJ: What created you look at joining the cannabis market? 

Jennifer: With my operate in topicals, transdermal and inhalation drug delivery, I had an simple understanding of the unique routes of administration we see currently in the cannabis market. And so, from the technologies standpoint, I believed this was a location I could contribute to promptly. And then what got me genuinely excited about it was pondering about cannabis, and just like any other drug, with oral drug delivery, you have got initially class metabolism and side effects from the 11-Hydroxy-THC that are undesirable and you’d rather not have delivered by way of the gut.

OLO sublingual strips have a 10-minute onset time

I got excited when I saw the improvement of issues like sublingual strips that had been focusing on options to smoking that would preserve that somewhat rapidly onset and mitigate some of the side effects of edibles.

The other issue I genuinely like about the cannabis market: Previously I have been really focused on identified drugs that are currently authorized and repurposing them into a new delivery program. What genuinely interests me about the cannabis market is the active cannabinoids and terpenes are somewhat identified and somewhat unknown, so there is this genuinely fascinating challenge there of attempting to separate the wheat from the chaff in terms of creating therapeutic effects.

It is a genuinely fascinating space exactly where the indications of specific molecules are evolving along with the delivery technologies. So, it is a genuinely thrilling and eye-opening way to take the subsequent step in my profession and have this wide-open space in front of me, each in terms of the unique cannabinoids, their effects and the delivery systems we can use.

CIJ: How could possibly you be ready, offered your background, for some of the challenges in the cannabis space?

Jennifer: I believe the challenges in cannabis delivery are not unique from the challenges in pharmaceutical drug delivery. It is just that we have this added complexity of the entourage impact. We can be engineering not just the major ingredient of THC, but also all the other cannabinoids and terpenes. So, for instance, with my background in infection prevention, we create a item that we know reduces the threat of infection, but we are genuinely challenged to truly prove it reduces the threat of infection. We have a equivalent predicament in the cannabis market, exactly where we can get the THC, or CBG or CBN exactly where we want it to go, but then we are genuinely challenged to figure out how we can come across, what we get in touch with in the pharmaceutical market, a surrogate finish point for efficacy, so that we can test that item and genuinely think that when we place the item on the marketplace, even even though we haven’t tested thousands of customers or performed substantial randomized clinical trials, that the impact will be shown. We are networking and partnering with a fantastic scientific neighborhood to create the ideal item and do some testing at a tiny scale that genuinely demonstrates the item achieves the impact that we are genuinely searching for.

CIJ: Can you inform us a tiny about your new function with Project Yosemite?

Jennifer: My job description falls into 3 buckets: The initially portion is that we are forming a scientific advisory board and we are operating with some of the top cannabinoid researchers about the nation and about the planet. These are the men and women identifying whether or not or not specific cannabinoids could lower cancer cell metabolism or whether or not cannabinoids contribute to weight loss or diabetes manage and other issues of that nature. We are attempting to attain as far upstream as we can to grasp the emerging understanding of the efficiency of cannabinoids and terpenes in the endocannabinoid program. So, portion of my job is to chair that scientific advisory board, get the believed leaders with each other in the space and have them bring their know-how and discover with our personal know-how what cannabis can genuinely do.

The OLO sublingual strips

I have worked in topical, transdermal, buccal, nasal, inhalation drug delivery. In the second bucket of my job, we are attempting to fully grasp a offered indication or knowledge that our customers want to have, what would be the ideal route for them. We are difficult our sublingual delivery mechanism to see how rapidly of an onset we can genuinely get. Proper now, we are at 10 minutes for drug delivery in sublingual and we are nevertheless attempting to get an even more quickly onset time for the sublingual strip.

For other indications, like chronic discomfort, we may perhaps want to believe about a sustained release, so sort of aligning the unique indications with which unique cannabinoids and terpenes will operate for it and see which delivery platform will operate for what we are attempting to achieve in every indication.  So, we do not program to stay solely a sublingual strip organization, but will create out added delivery platforms as we create new indications.

Proper now, we are operating upstream with the growers and the processors to get cannabis oil and extracts. Some of the growers are operating on unique genetics in their cultivars to develop plants that have unique ratios of unique cannabinoids that we know from the emerging study will have an effect on people’s knowledge. Now we are operating with growers to genuinely get ahead of the curve on how to formulate goods with a variety of cannabinoids.

We have an R&ampD group in property that I supervise. We are normally operating with our production group to make tiny improvements such as the more quickly onset and the dissolution price and issues like flavors, which covers a downstream concentrate as effectively.

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